Muscle-Derived Cytokines Reduce Growth, Viability and Migratory Activity of Pancreatic Cancer Cells

The evidence that regular physical exercise reduces the risk of developing cancer is well described. However, interaction between and not fully clarified yet. Several myokines released by skeletal muscle appear to have a direct anti-tumour function. There are few data on myokine secretion after in patients with advanced tumours. Pancreatic (PC) very aggressive usually fatal cancer. To investigate effects PC, blood advanced-stage PC was analysed 12 weeks resistance training using whole-body electromyostimulation. After 12-week period, patient serum inhibited proliferation motility cells enhanced cell apoptosis. impact also investigated an exercise-mimicking vitro model electric pulse stimulation human myotubes revealed similar cells, clearly indicating cancer-protective properties activated muscle. Protein gene expression analyses plasma from exercise-trained myotube cultures showed interleukin 10 (IL10), C-X-C motif ligand 1 (CXCL1) C-C chemokine 4 (CCL4) In accordance patients, supplementation recombinant IL10, CXCL1 CCL4 impaired growth migration cells. Treatment these upregulated caspase 3/7 cleavage poly(ADP-ribose) polymerase, leading death. identification opens new perspective supportive therapy sports for patients.